The Ras superfamily G-proteins.
| Autor: | Tetlow AL; Department of Microbiology, Immunology and Molecular Genetics, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California, USA., Tamanoi F; Department of Microbiology, Immunology and Molecular Genetics, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California, USA. Electronic address: fuyut@microbio.ucla.edu. |
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| Jazyk: | angličtina |
| Zdroj: | The Enzymes [Enzymes] 2013; Vol. 33 Pt A, pp. 1-14. Date of Electronic Publication: 2013 Aug 08. |
| DOI: | 10.1016/B978-0-12-416749-0.00001-4 |
| Abstrakt: | The Ras superfamily G-proteins are monomeric proteins of approximately 21kDa that act as a molecular switch to regulate a variety of cellular processes. The structure of the Ras superfamily G-proteins, their regulators as well as posttranslational modification of these proteins leading to their membrane association have been elucidated. The Ras superfamily G-proteins interact at their effector domains with their downstream effectors via protein-protein interactions. Mutational activation or overexpression of the Ras superfamily G-proteins has been observed in a number of human cancer cases. Over the years, a variety of approaches to inhibit the Ras superfamily G-proteins have been developed. These different approaches are discussed in this volume. (© 2013 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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