| Autor: |
Zaichko NV, Ol'khovs'kyĭ OS, Mel'nyk AV, Iurchenko PO, Hryhor"ieva HS, Konakhovych NF |
| Jazyk: |
ukrajinština |
| Zdroj: |
Ukrainian biochemical journal [Ukr Biochem J] 2014 May-Jun; Vol. 86 (3), pp. 69-76. |
| Abstrakt: |
The influence of microelement preparation Esmin on hydrogen sulfide (H2S) levels, activity of H2S-producing enzymes and indices of pro-/antioxidant system in the myocardium of different age rats were investigated. In the process of aging the levels of H2S and activities of H2S-producing enzymes (cysteine aminotransferase, cystathionine-gamma-lyase) are reduced in the myocardium; the pro-/antioxidant balance is destabilized (NADPH-oxidase activity is increased and thioredoxin reductase activity is decreased). Esmin administration effectively reduces age-related changes in the myocardium of old rats: increases H2S levels and activity of H2S-producing enzymes, restores pro-/antioxidant balance. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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