The RcsCDB regulatory system plays a crucial role in the protection of Salmonella enterica serovar Typhimurium against oxidative stress.
| Autor: | Farizano JV; Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, and Instituto de Química Biológica 'Dr. Bernabé Bloj', Facultad de Bioquímica, Química y Farmacia, UNT. Chacabuco 461, T4000ILI - San Miguel de Tucumán, Argentina., Torres MA; Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, and Instituto de Química Biológica 'Dr. Bernabé Bloj', Facultad de Bioquímica, Química y Farmacia, UNT. Chacabuco 461, T4000ILI - San Miguel de Tucumán, Argentina., Pescaretti MLM; Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, and Instituto de Química Biológica 'Dr. Bernabé Bloj', Facultad de Bioquímica, Química y Farmacia, UNT. Chacabuco 461, T4000ILI - San Miguel de Tucumán, Argentina., Delgado MA; Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, and Instituto de Química Biológica 'Dr. Bernabé Bloj', Facultad de Bioquímica, Química y Farmacia, UNT. Chacabuco 461, T4000ILI - San Miguel de Tucumán, Argentina. |
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| Jazyk: | angličtina |
| Zdroj: | Microbiology (Reading, England) [Microbiology (Reading)] 2014 Oct; Vol. 160 (Pt 10), pp. 2190-2199. Date of Electronic Publication: 2014 Jul 15. |
| DOI: | 10.1099/mic.0.081133-0 |
| Abstrakt: | Dps, the most abundant protein during the stationary growth phase, in Salmonella enterica is required for resistance to reactive oxygen species produced by the host during infection. It has been reported that in Salmonella dps expression is controlled by RpoS and Fur proteins. However, the regulation and function of Dps remain to be resolved. In the present work we demonstrate that activation of the complex RcsCDB regulatory system increases dps expression during exponential growth of Salmonella. In addition, we show that such dps upregulation produces high levels of H2O2 resistance. This phenotype allows the bacteria to avoid reactive oxygen species killing at early stages of growth, thus protecting its genetic material. (© 2014 The Authors.) |
| Databáze: | MEDLINE |
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