Enantioselective annulations for dihydroquinolones by in situ generation of azolium enolates.
| Autor: | Lee A; Department of Chemistry, Center for Molecular Innovation and Drug Discovery, Chemistry of Life Processes Institute, Northwestern University , Silverman Hall, Evanston, Illinois 60208, United States., Younai A, Price CK, Izquierdo J, Mishra RK, Scheidt KA |
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| Jazyk: | angličtina |
| Zdroj: | Journal of the American Chemical Society [J Am Chem Soc] 2014 Jul 30; Vol. 136 (30), pp. 10589-92. Date of Electronic Publication: 2014 Jul 15. |
| DOI: | 10.1021/ja505880r |
| Abstrakt: | A convergent, catalytic asymmetric formal [4 + 2] annulation for the synthesis of dihydroquinolones has been developed. Carboxylic acids can be employed as precursors to NHC enolates through an in situ activation strategy. Simultaneous generation of a reactive aza-o-quinone methide under the basic conditions employed for NHC generation leads to a dual activation approach. |
| Databáze: | MEDLINE |
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