Resistance training after myocardial infarction in rats: its role on cardiac and autonomic function.

Autor:	Grans CF; Laboratório do Movimento Humano, Universidade São Judas Tadeu, São Paulo, SP, Brazil., Feriani DJ; Laboratório do Movimento Humano, Universidade São Judas Tadeu, São Paulo, SP, Brazil., Abssamra ME; Laboratório do Movimento Humano, Universidade São Judas Tadeu, São Paulo, SP, Brazil., Rocha LY; Laboratório do Movimento Humano, Universidade São Judas Tadeu, São Paulo, SP, Brazil., Carrozzi NM; Laboratório do Movimento Humano, Universidade São Judas Tadeu, São Paulo, SP, Brazil., Mostarda C; Departamento de Educação Física, Universidade Federal do Maranhão, São Luís, MA, Brazil., Figueroa DM; Laboratório de Hipertensão Experimental, Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil., Angelis KD; Laboratório de Fisiologia Translacional, Universidade Nove de Julho, São Paulo, SP, Brazil., Irigoyen MC; Laboratório de Hipertensão Experimental, Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil., Rodrigues B; Laboratório do Movimento Humano, Universidade São Judas Tadeu, São Paulo, SP, Brazil.
Jazyk:	English; Portuguese
Zdroj:	Arquivos brasileiros de cardiologia [Arq Bras Cardiol] 2014 Jul; Vol. 103 (1), pp. 60-8. Date of Electronic Publication: 2014 Jul 09.
DOI:	10.5935/abc.20140093
Abstrakt:	Background: Although resistance exercise training is part of cardiovascular rehabilitation programs, little is known about its role on the cardiac and autonomic function after myocardial infarction. Objective: To evaluate the effects of resistance exercise training, started early after myocardial infarction, on cardiac function, hemodynamic profile, and autonomic modulation in rats. Methods: Male Wistar rats were divided into four groups: sedentary control, trained control, sedentary infarcted and trained infarcted rats. Each group with n = 9 rats. The animals underwent maximum load test and echocardiography at the beginning and at the end of the resistance exercise training (in an adapted ladder, 40% to 60% of the maximum load test, 3 months, 5 days/week). At the end, hemodynamic, baroreflex sensitivity and autonomic modulation assessments were made. Results: The maximum load test increased in groups trained control (+32%) and trained infarcted (+46%) in relation to groups sedentary control and sedentary infarcted. Although no change occurred regarding the myocardial infarction size and systolic function, the E/A ratio (-23%), myocardial performance index (-39%) and systolic blood pressure (+6%) improved with resistance exercise training in group trained infarcted. Concomitantly, the training provided additional benefits in the high frequency bands of the pulse interval (+45%), as well as in the low frequency band of systolic blood pressure (-46%) in rats from group trained infarcted in relation to group sedentary infarcted. Conclusion: Resistance exercise training alone may be an important and safe tool in the management of patients after myocardial infarction, considering that it does not lead to significant changes in the ventricular function, reduces the global cardiac stress, and significantly improves the vascular and cardiac autonomic modulation in infarcted rats.
Databáze:	MEDLINE
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