| Autor: |
Andreoli SC; Universidade Católica de Brasília, Brasilia, DF, Brazil., Gasparini NJ; Universidade Católica de Brasília, Brasilia, DF, Brazil., de Carvalho GP; Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil., Garicochea B; Centro de Oncologia Sírio Libanês, São Paulo, SP, Brazil., Pogue RE; Universidade Católica de Brasília, Brasilia, DF, Brazil., de Andrade RV; Universidade Católica de Brasília, Brasilia, DF, Brazil. |
| Abstrakt: |
Colorectal cancer is the third most common cancer worldwide. Survival and prognosis depend on tumor stage upon diagnosis, and in more than 50% of cases, the tumor has already invaded adjacent tissues or metastasis has occurred. Aiming to improve diagnosis, clinical prognosis and treatment of patients with colorectal cancer, several studies have investigated microRNAs as molecular markers of the disease due to their potential regulatory functions on tumor suppressor genes and oncogenes. This review aimed to summarize the main topics related to the use of microRNAs in diagnosis, clinical prognosis and evaluating treatment response in colorectal cancer. |
