Oral antioxidants supplementation for women with unexplained infertility undergoing ICSI/IVF: randomized controlled trial.

Autor: Youssef MA; Department of Obstetrics and Gynaecology, Faculty of Medicine, Cairo University , Cairo , Egypt., Abdelmoty HI, Elashmwi HA, Abduljawad EM, Elghamary N, Magdy A, Mohesen MN, Abdella RM, Bar MA, Gouda HM, Ali AM, Raslan AN, Youssef D, Sherif NA, Ismail AI
Jazyk: angličtina
Zdroj: Human fertility (Cambridge, England) [Hum Fertil (Camb)] 2015 Mar; Vol. 18 (1), pp. 38-42. Date of Electronic Publication: 2014 Jul 03.
DOI: 10.3109/14647273.2014.927595
Abstrakt: Objective: Good oocyte quality and maturity are important prerequisites for high fertilization and implantation rates in IVF/ICSI treatment cycles. Reactive oxygen species (ROS) are produced within ovarian follicles, especially during the ovulation process, and increased ROS activity may be a cause of impaired oocyte maturation and higher rate of failure of IVF/ICSI cycles.
Study Design: RCT evaluating the effect of antioxidant supplementation on ICSI/IVF outcomes. Two hundred and eighteen women with unexplained subfertility undergoing IVF/ICSI were randomized into two groups. The study group (n = 112) received daily oral antioxidants in the form of multivitamins and minerals (amino acid chelated) while the control group (n = 106) did not. Main outcomes were number of mature metaphase II (MII) oocytes and clinical pregnancy rate.
Results: There were no significant changes between the groups as regards age, BMI, basal FSH, number of mature (MII) oocytes (12.7 ± 9.4 vs. 13.2 ± 8.6, P = 0.7) and clinical pregnancy rate per woman randomized (38% vs. 34%; [OR = 1.2; 95% CI, 0.70-2.11].
Conclusion: Oral antioxidants in the form of a combination of multivitamins and minerals (amino acid chelated) did not improve oocyte quality and pregnancy rates in women with unexplained infertility undergoing IVF/ICSI treatment.
Databáze: MEDLINE
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