[A study of IL-1Β and IDO gene polymorphisms in patients with schizophrenia].

Autor:	Golimbet VE, Korovaĭtseva GI, Gabaeva MV, Velikaia NV, Snegireva AA, Kasparov SV, Kolesina NIu, Ganisheva TK, Savel'eva TM
Jazyk:	ruština
Zdroj:	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2014; Vol. 114 (5), pp. 46-9.
Abstrakt:	Objective: Neurotoxic metabolites of the kynurenine pathway are thought to be implicated in the pathogenesis of schizophrenia. The enzyme indoleamine 2,3-dioxygenase (IDO) catalyzes the initial step of the kynurenine pathway that converts tryptophan to kynurenine metabolites. IDO is induced by proinflammatory cytokines. We studied IL-1Β T-511C (rs16944), IL-1Β C3954T (rs1143634), IDO VNTR and IDO rs9657182 polymorphisms in patients with schizophrenia and controls. Material and Methods: Genotyping was performed in 296 patients with schizophrenia (ICD-10 F20.0) and 355 healthy controls. Results: The multiple dimension reduction (MDR) analysis revealed a combination included alleles С (T-511C), Т (C3954T), V1 (VNTR) and С (rs9657182), which was associated with schizophrenia (OR 3,3 CI 95% 2,3-4,8). Conclusion: This is the first report of the interaction between IL-1Β and IDO genes. Further research into genes of the kynurenine pathway is needed.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu