Assessment of Neutrophil/Lymphocyte Ratio in Patients with Age-related Macular Degeneration.

Autor: Ilhan N; a Department of Ophthalmology, Faculty of Medicine , Mustafa Kemal University , Antakya , Hatay , Turkey., Daglioglu MC; a Department of Ophthalmology, Faculty of Medicine , Mustafa Kemal University , Antakya , Hatay , Turkey., Ilhan O; a Department of Ophthalmology, Faculty of Medicine , Mustafa Kemal University , Antakya , Hatay , Turkey., Coskun M; a Department of Ophthalmology, Faculty of Medicine , Mustafa Kemal University , Antakya , Hatay , Turkey., Tuzcu EA; a Department of Ophthalmology, Faculty of Medicine , Mustafa Kemal University , Antakya , Hatay , Turkey., Kahraman H; a Department of Ophthalmology, Faculty of Medicine , Mustafa Kemal University , Antakya , Hatay , Turkey., Keskin U; a Department of Ophthalmology, Faculty of Medicine , Mustafa Kemal University , Antakya , Hatay , Turkey.
Jazyk: angličtina
Zdroj: Ocular immunology and inflammation [Ocul Immunol Inflamm] 2015 Aug; Vol. 23 (4), pp. 287-290. Date of Electronic Publication: 2014 Jul 02.
DOI: 10.3109/09273948.2014.921715
Abstrakt: Purpose: To investigate the neutrophil/lymphocyte ratio (NLR) as an indicator of inflammation in patients with age-related macular degeneration (AMD).
Methods: Patients were evaluated by a review of records. The study included 81 patients with dry AMD (group 1), 84 patients with wet AMD (group 2), and 80 healthy age- and sex-matched controls (group 3). The NLR of the patients was obtained from the hospital laboratory archive and was measured by dividing the neutrophil count by the lymphocyte count.
Results: A significant difference was found in NLR values between groups 1 and 2 (p = 0.017), groups 2 and 3 (p < 0.001), and groups 1 and 3 (p < 0.001). In correlation analyses, NLR was correlated positively with age (r = 0.22, p <0.001) and disease severity (r = 0.40, p < 0.001).
Conclusions: Patients with AMD have higher NLR compared with controls, and NLR correlates with disease severity. NLR may be used as a biomarker of inflammation in AMD.
Databáze: MEDLINE
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