Immunoglobulin genes influence the magnitude of humoral immunity to cytomegalovirus glycoprotein B.

Autor:	Pandey JP; Department of Microbiology and Immunology., Kistner-Griffin E; Department of Public Health Sciences, Medical University of South Carolina, Charleston., Radwan FF; Department of Microbiology and Immunology., Kaur N; Department of Microbiology and Immunology., Namboodiri AM; Department of Microbiology and Immunology., Black L; Department of Microbiology and Immunology., Butler MA; National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio., Carreón T; National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio., Ruder AM; National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2014 Dec 01; Vol. 210 (11), pp. 1823-6. Date of Electronic Publication: 2014 Jun 27.
DOI:	10.1093/infdis/jiu367
Abstrakt:	Human cytomegalovirus (HCMV) is a risk factor for many human diseases, but among exposed individuals, not everyone is equally likely to develop HCMV-spurred diseases, implying the presence of host genetic factors that might modulate immunity to this virus. Here, we show that antibody responsiveness to HCMV glycoprotein B (gB) is significantly associated with particular immunoglobulin GM (γ marker) genotypes. Anti-HCMV gB antibody levels were highest in GM 17/17 homozygotes, intermediate in GM 3/17 heterozygotes, and lowest in GM 3/3 homozygotes (28.2, 19.0, and 8.1 µg/mL, respectively; P=.014). These findings provide mechanistic insights in the etiopathogenesis of HCMV-spurred diseases. (© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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