Reverse transcriptase inhibitors drug resistance mutations in drug-naive HIV type 1 positive Kenyans.
| Autor: | Nyamache AK, Waihenya R, Ng'ang'a ZW, Muigai AW, Khamadi SA |
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| Jazyk: | angličtina |
| Zdroj: | East African medical journal [East Afr Med J] 2011 Jan; Vol. 88 (1), pp. 4-8. |
| Abstrakt: | Objective: To evaluate the extent of HIV-1 drug resistance among drug naive Kenyan individuals. Design: Cross-sectional study. Setting: Kenya Medical Research Institute HIV laboratory Nairobi, Kenya. Subjects: A total of seventy eight HIV-1 positive drug naive subjects randomised from five Kenyan provincial hospitals between April and June 2004. Results: A major non-nucleoside reverse transcriptase (NNRTI) an associated mutation was found in one patient (1.3%). NNRTI associated resistance mutations were present at amino acid codon sites G98A (2.56%); K103E (1.3%) and L100F (3.57%) prevalences. Baseline resistance may compromise the response to standard NNRTI-based first-line ART in 1.3 % of the study subjects. Conclusion: This indicates in general, that drug resistance among HIV-1 positive drug naive individual is at low thresholds (1.3%) but the problem could be more serious than reported here. Continuous resistance monitoring is therefore warranted to maintain individual and population-level ART effectiveness. |
| Databáze: | MEDLINE |
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