TRPV2 in the development of experimental colitis.

Autor: Issa CM; School of Life Science and Technology, TongJi University, Shanghai, China; Discipline of Pathology, Bosch Institute and School of Medical Sciences, University of Sydney, Sydney, NSW, Australia., Hambly BD, Wang Y, Maleki S, Wang W, Fei J, Bao S
Jazyk: angličtina
Zdroj: Scandinavian journal of immunology [Scand J Immunol] 2014 Nov; Vol. 80 (5), pp. 307-12.
DOI: 10.1111/sji.12206
Abstrakt: Colitis is still a significant disease challenge in humans, but its underlying mechanism remains to be fully elucidated. The transient receptor potential vanilloid (TRPV) ion channel plays an important pathological role in host immunity, as deficiency of TRPV compromises host defence in vivo and in vitro. Using a DSS-induced colitis mouse model, the function of TRPV2 in the development of colitis was investigated, utilizing TRPV2(-/-) and Wt mice. Less severe colitis was observed in TRPV2(-/-) , compared to that of Wt mice, at the clinical, histopathological and immunohistochemical levels. Compared to Wt mice, reduced severity of colitis in TRPV2(-/-) mice may be due to less intestinal inflammation via reduced recruitment of macrophages. The TRPV2 pathway contributes to the development of colitis. These data provide useful information for potential therapeutic intervention in colitis patients.
(© 2014 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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