Functional Brain Activity Relates to 0-3 and 3-8 Hz Force Oscillations in Essential Tremor.

Autor:	Neely KA; Department of Kinesiology, The Pennsylvania State University, State College, PA, USA., Kurani AS; Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA., Shukla P; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA., Planetta PJ; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA., Wagle Shukla A; Department of Neurology and Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, USA., Goldman JG; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Corcos DM; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA Department of Physical Therapy and Human Movement Sciences, Northwestern University, Evanston, IL, USA., Okun MS; Department of Neurology and Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, USA., Vaillancourt DE; Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA Department of Neurology and Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, USA Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.
Jazyk:	angličtina
Zdroj:	Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2015 Nov; Vol. 25 (11), pp. 4191-202. Date of Electronic Publication: 2014 Jun 24.
DOI:	10.1093/cercor/bhu142
Abstrakt:	It is well-established that during goal-directed motor tasks, patients with essential tremor have increased oscillations in the 0-3 and 3-8 Hz bands. It remains unclear if these increased oscillations relate to activity in specific brain regions. This study used task-based functional magnetic resonance imaging to compare the brain activity associated with oscillations in grip force output between patients with essential tremor, patients with Parkinson's disease who had clinically evident tremor, and healthy controls. The findings demonstrate that patients with essential tremor have increased brain activity in the motor cortex and supplementary motor area compared with controls, and this activity correlated positively with 3-8 Hz force oscillations. Brain activity in cerebellar lobules I-V was reduced in essential tremor compared with controls and correlated negatively with 0-3 Hz force oscillations. Widespread differences in brain activity were observed between essential tremor and Parkinson's disease. Using functional connectivity analyses during the task evidenced reduced cerebellar-cortical functional connectivity in patients with essential tremor compared with controls and Parkinson's disease. This study provides new evidence that in essential tremor 3-8 Hz force oscillations relate to hyperactivity in motor cortex, 0-3 Hz force oscillations relate to the hypoactivity in the cerebellum, and cerebellar-cortical functional connectivity is impaired. (Published by Oxford University Press 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu