Linezolid-induced lactic acidosis corrected with sustained low-efficiency dialysis: a case report.
| Autor: | Sawyer AJ; Huntsville Hospital, Huntsville, AL. Electronic address: adam.sawyer@hhsys.org., Haley HL; Huntsville Hospital, Huntsville, AL. Electronic address: haley0513@gmail.com., Baty SR; Huntsville Hospital, Huntsville, AL., McGuffey GE; Huntsville Hospital, Huntsville, AL., Eiland EH 3rd; Huntsville Hospital, Huntsville, AL. |
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| Jazyk: | angličtina |
| Zdroj: | American journal of kidney diseases : the official journal of the National Kidney Foundation [Am J Kidney Dis] 2014 Sep; Vol. 64 (3), pp. 457-9. Date of Electronic Publication: 2014 Jun 21. |
| DOI: | 10.1053/j.ajkd.2014.04.032 |
| Abstrakt: | Linezolid, an oxazolidinone antibiotic, has been reported to increase the risk of lactic acidosis and peripheral neuropathy because it disrupts mitochondrial function. This case report describes the development of lactic acidosis in a 63-year-old man who had received 3 months of treatment with intravenous linezolid for pulmonary nocardiasis, and correction of the acidotic state with sustained low-efficiency dialysis. This case demonstrates that renal replacement therapy can be an alternative to discontinuation alone for rapid reversal of linezolid-induced lactic acidosis. (Copyright © 2014 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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