| Autor: |
Sawadogo A; Service d'hépato-gastro-entérologie du CHU Sanou Sourô (CHUSS), 01 BP 676, Bobo-Dioulasso 01, Burkina Faso, drsawadogo.appolinaire@yahoo.fr., Sanou S, Hema A, Kamboule BE, Kabore NF, Sore I, Konate A, Poda GE, Zoungrana J, Sawadogo AB |
| Jazyk: |
francouzština |
| Zdroj: |
Bulletin de la Societe de pathologie exotique (1990) [Bull Soc Pathol Exot] 2014 Aug; Vol. 107 (3), pp. 151-8. Date of Electronic Publication: 2014 Jun 23. |
| DOI: |
10.1007/s13149-014-0371-8 |
| Abstrakt: |
Highly active antiretroviral therapy (HAART) has reduced morbidity and mortality of HIV but has led to an increasing metabolic cardiovascular risk. A cross-sectional study was conducted from May to September 2011 in Day Care Hospital for HIV-Patients of Bobo-Dioulasso. We included in this study 400 patients infected by HIVon antiretroviral therapy ≥ 6 months selected by a random draw. Metabolic syndrome was assessed according to the definitions of the IDF and ATP-III. The high risk of cardiovascular disease in 10 years was defined by a Framingham score ≥ 20%. The average age of our patients was 41.4 years [20-76]. 17% received an IP. The average duration of PI exposure was 35.5 months and 50.1 months for NNRTI. The prevalence of diabetes was 1.3% (95% CI: 0.5-3) and that of hypertension of 12.0 % (95% CI: 9.3-16). The prevalence of metabolic syndrome according to IDF was 10% (95% CI: 7.3-13.5) and the metabolic syndrome according to ATP-III 12.3% (95% CI: 9.3-16). The body mass index was higher (BMI 25.2 vs. 22.5 kg/m(2), p <10(-3) with ATPIII and BMI 26.6 vs. 22.4 kg/m(2), p <10(-3) with IDF), and duration exposure to ARVs longer in patients with metabolic syndrome regardless of the definition used (58.6 months vs 27.9 months). High cardiovascular risk was present in 1.8% (95% CI: 0.8 to 3.7) of our patients, all male more than half (n=4/7) of them were smoking. The choice of antiretroviral therapy must take into account its potential long-term toxicity. It should also strengthen supervision. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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