| Autor: |
Obut TA; Research Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia., Ovsyukova MV, Egorova SA, Erdynieva TA, Dement'eva TY, Obut ET, Gorobchuk AG |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2014 Jun; Vol. 157 (2), pp. 231-3. Date of Electronic Publication: 2014 Jun 22. |
| DOI: |
10.1007/s10517-014-2532-y |
| Abstrakt: |
Male rats were exposed to single or repeated (19 days) cold treatment (4°C) and non-cold stress (60-min shaking on a laboratory shuttle device). Retabolil had a hypotensive effect, which was accompanied by the prevention of a stress-induced increase in the concentration of a hypertensive hormone aldosterone. Under conditions of repeated stress, these effects were realized via μ-opioid receptors. Our results suggest that retabolil can be used as a hypotensive and aldosterone-blocking agent, at least during stress exposure in animals (and probably in humans). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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