ADAM10 is required for SCF-induced mast cell migration.

Autor: Faber TW; Department of Biology, Virginia Commonwealth University (VCU), Richmond, VA 23284-2012, United States., Pullen NA; Department of Biology, Virginia Commonwealth University (VCU), Richmond, VA 23284-2012, United States., Fernando JF; Department of Biology, Virginia Commonwealth University (VCU), Richmond, VA 23284-2012, United States., Kolawole EM; Department of Biology, Virginia Commonwealth University (VCU), Richmond, VA 23284-2012, United States., McLeod JJ; Department of Biology, Virginia Commonwealth University (VCU), Richmond, VA 23284-2012, United States., Taruselli M; Department of Biology, Virginia Commonwealth University (VCU), Richmond, VA 23284-2012, United States., Williams KL; Department of Biology, Virginia Commonwealth University (VCU), Richmond, VA 23284-2012, United States., Rivera KO; Department of Biology, Virginia Commonwealth University (VCU), Richmond, VA 23284-2012, United States., Barnstein BO; Department of Biology, Virginia Commonwealth University (VCU), Richmond, VA 23284-2012, United States., Conrad DH; Department of Microbiology and Immunology, Virginia Commonwealth University (VCU), Richmond, VA 23284-2012, United States., Ryan JJ; Department of Biology, Virginia Commonwealth University (VCU), Richmond, VA 23284-2012, United States. Electronic address: jjryan@vcu.edu.
Jazyk: angličtina
Zdroj: Cellular immunology [Cell Immunol] 2014 Jul; Vol. 290 (1), pp. 80-8. Date of Electronic Publication: 2014 May 21.
DOI: 10.1016/j.cellimm.2014.05.005
Abstrakt: A Disintegrin and Metalloproteinase (ADAM)-10 plays critical roles in neuronal migration and distribution. Recently, ADAM10 deletion was shown to disrupt myelopoiesis. We found that inducible deletion of ADAM10 using Mx1-driven Cre recombinase for a period of three weeks resulted in mast cell hyperplasia in the skin, intestine and spleen. Mast cells express surface ADAM10 in vitro and in vivo, at high levels compared to other immune cells tested. ADAM10 is important for mast cell migration, since ADAM10-deficiency reduced c-Kit-mediated migration. As with some mast cell proteases, ADAM10 expression could be altered by the cytokine microenvironment, being inhibited by IL-10 or TGFβ1, but not by several other T cell-derived cytokines. Collectively these data show that the ADAM10 protease is an important factor in mast cell migration and tissue distribution, and can be manipulated by environmental cues.
(Copyright © 2014 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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