| Autor: |
Colacurci N; Outpatient Fertility Clinic, Second University of Naples , Naples , Italy., Caprio F, La Verde E, Trotta C, Ianniello R, Mele D, De Franciscis P |
| Jazyk: |
angličtina |
| Zdroj: |
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2014 Oct; Vol. 30 (10), pp. 730-3. Date of Electronic Publication: 2014 Jun 20. |
| DOI: |
10.3109/09513590.2014.927856 |
| Abstrakt: |
A stimulation protocol mimicking the physiological pattern of FSH release may improve IVF outcome in women of advanced age. Urinary-FSH delivers a wider range of isoforms including the most acidic produced during the early follicular phase when oestradiol level is low, a common condition in women of advanced reproductive age. We hypothesized that a stimulation protocol using urinary-FSH during the early follicular phase and then shifting toward recombinant-FSH may improve oocyte quality and pregnancy rate in 35-40 years old patients in IVF program. A retrospective study was performed: after a standard down-regulation with GnRH-analogue, 115 women underwent stimulation with urinary-FSH for 6 days according to a step-down approach and then shifting to recombinant-FSH (group A), 115 women underwent a stimulation protocol with only recombinant-FSH (group B). Days of stimulation were lower in group A than in group B, a higher proportion of MII oocytes and of grade 1 embryos, higher implantation rate and pregnancy rate were observed in group A versus group B. We conclude that a sequential protocol using urinary-FSH in the early days of stimulation and subsequently recombinant-FSH may improve the IVF outcome in patients of advanced reproductive age. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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