| Autor: |
Kirchhoff AC; Cancer Control and Population Sciences Research Program, Huntsman Cancer Institute , Salt Lake City, Utah. ; Center for Children's Cancer Research, Huntsman Cancer Institute , Salt Lake City, Utah. ; Department of Pediatrics, University of Utah , Salt Lake City, Utah., Spraker-Perlman HL; Center for Children's Cancer Research, Huntsman Cancer Institute , Salt Lake City, Utah. ; Department of Pediatrics, University of Utah , Salt Lake City, Utah., McFadden M; Division of Epidemiology, Department of Internal Medicine, University of Utah , Salt Lake City, Utah., Warner EL; Cancer Control and Population Sciences Research Program, Huntsman Cancer Institute , Salt Lake City, Utah., Oeffinger KC; Departments of Medicine and Pediatrics, Memorial Sloan-Kettering Cancer Center , New York, New York., Wright J; Center for Children's Cancer Research, Huntsman Cancer Institute , Salt Lake City, Utah. ; Department of Pediatrics, University of Utah , Salt Lake City, Utah., Kinney AY; Department of Internal Medicine and University of New Mexico Cancer Center, University of New Mexico , Albuquerque, New Mexico . |
| Abstrakt: |
Purpose: Survivors of cancer diagnosed during adolescence and young adulthood (AYA; aged 15-39) may experience quality of life (QOL) limitations; however, little is known about QOL for AYA survivors who are now middle-aged or among racial/ethnic minority survivors. We evaluated QOL outcomes for AYA cancer survivors relative to a non-cancer comparison group by gender, race/ethnicity, and current age. Methods: Using the 2009 Behavioral Risk Factor Surveillance System (BRFSS) data, we identified 8375 individuals diagnosed with cancer while aged 15-39 years old and 334,759 controls. Participants were currently ≥20 years of age. QOL was measured using four items from the Center for Disease Control's Healthy Days Measure (general health, number of days of poor physical and mental health, and activity limitation days). Multivariable regressions compared these measures for survivors and controls by gender, race/ethnicity, and age, and among survivors to determine cancer-related factors associated with poor QOL. Results: Survivors were more likely to report fair/poor general health than controls (relative risk=1.92; 95% confidence interval: 1.77-2.10; p <0.001). QOL limitations existed by gender and race/ethnicity for survivors. Approximately 30% of survivors currently in their 40s, 50s, and early 60s were in poor health, compared to less than 20% of same-aged controls (both p <0.001). Of survivors with two or more cancers, 41.0% reported poor health, compared to 26.2% with one cancer ( p <0.001). Conclusion: AYA cancer survivors have worse QOL compared to the general population and these limitations persist across gender, race/ethnicity, and age. Targeted interventions are essential for improving AYA cancer survivors' health status. |
