Abnormal brain structure in youth who commit homicide.

Autor:	Cope LM; Mind Research Network and Lovelace Biomedical and Environmental Research Institute, 1101 Yale Blvd. NE, Albuquerque, NM 87106, USA ; University of New Mexico, MSC03 2220, Albuquerque, NM 87131, USA., Ermer E; Mind Research Network and Lovelace Biomedical and Environmental Research Institute, 1101 Yale Blvd. NE, Albuquerque, NM 87106, USA ; Derner Institute of Advanced Psychological Studies, Adelphi University, P.O. Box 701, Garden City, NY 11530, USA., Gaudet LM; Mind Research Network and Lovelace Biomedical and Environmental Research Institute, 1101 Yale Blvd. NE, Albuquerque, NM 87106, USA., Steele VR; Mind Research Network and Lovelace Biomedical and Environmental Research Institute, 1101 Yale Blvd. NE, Albuquerque, NM 87106, USA ; University of New Mexico, MSC03 2220, Albuquerque, NM 87131, USA., Eckhardt AL; Mind Research Network and Lovelace Biomedical and Environmental Research Institute, 1101 Yale Blvd. NE, Albuquerque, NM 87106, USA ; University of New Mexico, MSC03 2220, Albuquerque, NM 87131, USA., Arbabshirani MR; Mind Research Network and Lovelace Biomedical and Environmental Research Institute, 1101 Yale Blvd. NE, Albuquerque, NM 87106, USA ; University of New Mexico, MSC03 2220, Albuquerque, NM 87131, USA., Caldwell MF; Mind Research Network and Lovelace Biomedical and Environmental Research Institute, 1101 Yale Blvd. NE, Albuquerque, NM 87106, USA ; Mendota Mental Health Institute, 301 Troy Dr., Madison, WI 53704, USA., Calhoun VD; Mind Research Network and Lovelace Biomedical and Environmental Research Institute, 1101 Yale Blvd. NE, Albuquerque, NM 87106, USA ; University of New Mexico, MSC03 2220, Albuquerque, NM 87131, USA., Kiehl KA; Mind Research Network and Lovelace Biomedical and Environmental Research Institute, 1101 Yale Blvd. NE, Albuquerque, NM 87106, USA ; University of New Mexico, MSC03 2220, Albuquerque, NM 87131, USA.
Jazyk:	angličtina
Zdroj:	NeuroImage. Clinical [Neuroimage Clin] 2014 May 10; Vol. 4, pp. 800-7. Date of Electronic Publication: 2014 May 10 (Print Publication: 2014).
DOI:	10.1016/j.nicl.2014.05.002
Abstrakt:	Background: Violence that leads to homicide results in an extreme financial and emotional burden on society. Juveniles who commit homicide are often tried in adult court and typically spend the majority of their lives in prison. Despite the enormous costs associated with homicidal behavior, there have been no serious neuroscientific studies examining youth who commit homicide. Methods: Here we use neuroimaging and voxel-based morphometry to examine brain gray matter in incarcerated male adolescents who committed homicide (n = 20) compared with incarcerated offenders who did not commit homicide (n = 135). Two additional control groups were used to understand further the nature of gray matter differences: incarcerated offenders who did not commit homicide matched on important demographic and psychometric variables (n = 20) and healthy participants from the community (n = 21). Results: Compared with incarcerated adolescents who did not commit homicide (n = 135), incarcerated homicide offenders had reduced gray matter volumes in the medial and lateral temporal lobes, including the hippocampus and posterior insula. Feature selection and support vector machine learning classified offenders into the homicide and non-homicide groups with 81% overall accuracy. Conclusions: Our results indicate that brain structural differences may help identify those at the highest risk for committing serious violent offenses.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu