| Autor: |
Ahangar-Oskouee M; Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran E-mail : shahmahmoodi@tums.ac.ir., Shahmahmoodi S, Jalilvand S, Mahmoodi M, Ziaee AA, Esmaeili HA, Keshtvarz M, Pishraft-Sabet L, Yousefi M, Mollaei-Kandelous Y, Mokhtari-Azad T, Nategh R |
| Jazyk: |
angličtina |
| Zdroj: |
Asian Pacific journal of cancer prevention : APJCP [Asian Pac J Cancer Prev] 2014; Vol. 15 (9), pp. 4061-5. |
| DOI: |
10.7314/apjcp.2014.15.9.4061 |
| Abstrakt: |
The presence of viral DNA in breast cancer cells is controversial. However, some studies have revealed a possible role for the human papillomavirus in the pathogenesis of breast cancer. The aim of the present study was to investigate the presence of HPV-DNA in breast tissue in a group of Iranian women with and without breast cancer and identification of the detected HPV types. Paraffin-embedded specimens from 65 malignant breast cancer cases and 65 cases with benign breast lesions were investigated for presence of HPV-DNA by nested polymerase chain reaction. We found HPV-DNA in 22 (33.8%) of the breast cancer specimens. All non-cancerous specimens were negative. Low and high-risk HPV types, including HPV-6 (26.2%), HPV-16 (1.5%), HPV-35 (1.5%), HPV-52 (1.5%), and HPV-11 (1.5%) were detected in our study. HPV-6 was the most prevalent type in the breast cancer specimens. Although high-risk HPV types have been shown to have a major role in cervix cancer, there have been no data that support the same relevance for other types of malignancies. Furthermore, presence of low-risk HPV types in malignancies still is a matter of debate. The data presented in this study indicates a strong need for epidemiological studies correlating different HPV types in human breast cancer. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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