| Autor: |
Tushurashvili PR; Department of Biophysics, Tbilisi State University, USSR., Dekanosidze NZ, Inasaridze NP, Kekelidze TN, Tsartsidze MA, Lomsadze BA |
| Jazyk: |
angličtina |
| Zdroj: |
FEBS letters [FEBS Lett] 1989 Feb 27; Vol. 244 (2), pp. 268-70. |
| DOI: |
10.1016/0014-5793(89)80542-3 |
| Abstrakt: |
Preincubation of submitochondrial particles (SMP) from beef heart in a reaction mixture containing low concentrations of Mg2+ induces a time lag in the NADH:oxidase activity. Preconditioning of the SMP by NADH, but not by NAD+, prevents the Mg2+-related time lag. The data obtained show that there exists a tight binding site for Mg2+ regulating the rate of electron transfer from NADH to the natural acceptor. The ability of Mg2+ to form a catalytically inactive complex with the enzyme is regulated by NADH. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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