Isolated hyperthyrotropinemia in childhood obesity and its relation with metabolic parameters.

Autor: Unüvar T; Department of Pediatric Endocrinology, Medical Faculty, Adnan Menderes University, Aydın, 09100, Turkey, tunuvar@gmail.com., Anık A, Catlı G, Esen I, Abacı A, Büyükgebiz A, Böber E
Jazyk: angličtina
Zdroj: Journal of endocrinological investigation [J Endocrinol Invest] 2014 Sep; Vol. 37 (9), pp. 799-804. Date of Electronic Publication: 2014 Jun 12.
DOI: 10.1007/s40618-014-0100-y
Abstrakt: Purpose: The aim of the presented study was to evaluate the prevalence of isolated hyperthyrotropinemia (IH) in obese children and the relation between anthropometric and metabolic parameters.
Methods: Hospital records of the children, who presented to the Pediatric Endocrinology outpatient clinic of our institution with obesity, and age and gender-matched healthy children, who had undergone thyroid function test for any reason were retrospectively reviewed.
Results: The prevalence of IH was significantly higher in the obese group than in the controls (9.2 and 3.8 %, respectively). Body mass index-standard deviation score (BMI-SDS), thyroid-stimulating hormone (TSH), lipid parameters were significantly different in the obese group than in the control group. A positive correlation between TSH and BMI-SDS and negative correlation between TSH and free T4 (fT4) levels were found in obese subjects. Stepwise multiple linear regression analysis confirmed that BMI-SDS, fT4 and triglyceride levels were the strongest independent variables correlated with TSH level in obese subjects (r (2) = 0.046, p = 0.001).
Conclusions: IH prevalence is higher in obese children as compared to healthy children and the increase in TSH level correlates negatively with serum fT4 and positively with BMI-SDS and triglyceride levels in obese children.
Databáze: MEDLINE
Externí odkaz: