Characterisation of familial colorectal cancer Type X, Lynch syndrome, and non-familial colorectal cancer.

Autor: Shiovitz S; 1] Department of Medicine, University of Washington, Seattle, WA, USA [2] Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Copeland WK; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Passarelli MN; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Burnett-Hartman AN; 1] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA [2] Department of Epidemiology, University of Washington, Seattle, WA, USA., Grady WM; 1] Department of Medicine, University of Washington, Seattle, WA, USA [2] Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA [3] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Potter JD; 1] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA [2] Department of Epidemiology, University of Washington, Seattle, WA, USA [3] Centre for Public Health Research, Massey University, Wellington, New Zealand., Gallinger S; Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Buchanan DD; 1] University of Melbourne, Parkville, VIC, Australia [2] Cancer and Population Studies Group, Queensland Institute of Medical Research, Brisbane, QLD, Australia., Rosty C; 1] Cancer and Population Studies Group, Queensland Institute of Medical Research, Brisbane, QLD, Australia [2] University of Queensland, School of Medicine, Herston, QLD, Australia [3] Envoi Pathology, Herston, QLD, Australia., Win AK; University of Melbourne, Parkville, VIC, Australia., Jenkins M; University of Melbourne, Parkville, VIC, Australia., Thibodeau SN; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Haile R; Stanford Cancer Institute, Palo Alto, CA, USA., Baron JA; Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Marchand LL; University of Hawaii Cancer Center, Honolulu, HI, USA., Newcomb PA; 1] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA [2] Department of Epidemiology, University of Washington, Seattle, WA, USA., Lindor NM; Department of Health Science Research, Mayo Clinic, Scottsdale, AZ, USA.
Jazyk: angličtina
Zdroj: British journal of cancer [Br J Cancer] 2014 Jul 29; Vol. 111 (3), pp. 598-602. Date of Electronic Publication: 2014 Jun 10.
DOI: 10.1038/bjc.2014.309
Abstrakt: Background: Familial Colorectal Cancer Type X (FCCTX) is defined as individuals with colorectal cancer (CRC) who families meet Amsterdam Criteria-1 (AC1), but whose tumours are DNA-mismatch-repair-proficient, unlike Lynch syndrome (LS). FCCTX does not have an increased risk of extra-colonic cancers. This analysis compares epidemiologic and clinicopathologic features among FCCTX, LS, and 'non-familial' (non-AC1) CRC cases.
Methods: From the Colon Cancer Family Registry, FCCTX (n=173), LS (n=303), and non-AC1 (n=9603) CRC cases were identified. Questionnaire-based epidemiologic information and CRC pathologic features were compared across case groups using polytomous logistic regression.
Results: Compared with LS, FCCTX cases were less likely to be current (vs never) smokers; have a proximal subsite (vs rectal) tumour; or have mucinous histology, poor differentiation, or tumour-infiltrating lymphocytes. There were no observed differences in co-morbidities or medication usage.
Conclusions: FCCTX were less likely to be current tobacco users; other exposures were similar between these groups. Histopathologic differences highly suggestive of LS CRCs do not appear to be shared by FCCTX.
Databáze: MEDLINE
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