Polycystic ovary syndrome: implications of metabolic dysfunction.

Autor:	Avila MA; Department of Obstetrics and Gynecology, Federal University of Rio de Janeiro., Bruno RV; Institute of Gynecology, UFRJ., Barbosa FC; Mount Sinai New York Hospital., Andrade FC; HUCFF, UFRJ., Silva AC; Department of Psychiatry, Fluminense Federal University., Nardi AE; Department of Psychiatry, UFRJ.
Jazyk:	English; Portuguese
Zdroj:	Revista do Colegio Brasileiro de Cirurgioes [Rev Col Bras Cir] 2014 Mar-Apr; Vol. 41 (2), pp. 106-10.
DOI:	10.1590/s0100-69912014000200006
Abstrakt:	Objective: To determine the prevalence of metabolic syndrome (MS) and its clinical interrelations in polycystic ovary syndrome (PCOS). Methods: This was a cross-sectional, prospective study with 100 patients with diagnosed PCOS based on the consensus of Rotterdam (2003). We investigated the interrelationships of MS, with intrinsic PCOS data. Dermatological profile was analyzed, in addition to acanthosis nigricans (AN) in the presence of hirsutism and acne. The use of HOMA-IR (homeostatic model assessment of insulin resistance) aimed at the correlation with MS in order to establish the metabolic dysfunction with the state of insulin resistance. Results: The mean and standard deviations corresponding figures for age, body mass index and waist circumference were, respectively, 25.72 (± 4.87), 30.63 (± 9.31) and 92.09 (± 18.73). The prevalence of MS was 36% and significantly correlated with BMI, AN, and in 51% of patients the state of insulin resistance (HOMA-IR). Regarding skin profile, only AN significant correlation with MS. Conclusion: We propose the routine inspection of metabolic components related to severe PCOS. These parameters configure the cardiovascular risk and such conduct is of undoubted importance to public health.
Databáze:	MEDLINE
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