Neuromodulatory role of Bacopa monnieri on oxidative stress induced by postnatal exposure to decabromodiphenyl ether (PBDE -209) in neonate and young female mice.
| Autor: | Verma P; Department of Zoology, Mahila Mahavidyalaya, Banaras Hindu University, Varanasi 221005, India., Singh P; Department of Zoology, Mahila Mahavidyalaya, Banaras Hindu University, Varanasi 221005, India., Gandhi BS; Department of Zoology, Mahila Mahavidyalaya, Banaras Hindu University, Varanasi 221005, India. |
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| Jazyk: | angličtina |
| Zdroj: | Iranian journal of basic medical sciences [Iran J Basic Med Sci] 2014; Vol. 17 (4), pp. 307-11. |
| Abstrakt: | Objectives: Bacopa monnieri (BM), a traditional ayurvedic medicine, is a well-known memory enhancer. We have explored the role of BM against decabrominated diphenyl ether (PBDE-209)-induced alterations in neonate and young female mice. Materials and Methods: Mice were orally administered with B. monnieri at the doses of 40, 80 or 120 mg/kg body weight along with PBDE-209 (20 mg/kg body weight) from postnatal day (PND) 3-10. Levels of malondialdehyde, protein carbonyl and activities of superoxide dismutase and glutathione peroxidase were measured at both ages. The correct choices and reference/working memory errors of young mice were evaluated by Morris water and radial arm maze. Results: The results showed that BM at the dose of 120 mg/kg significantly (P<0.05) restored the levels of oxidants and the activities of antioxidant enzymes in frontal cortex and hippocampus of neonates against PBDE-209-induced toxicity. Conclusion: BM plays a neuroprotective role against PBDE-209-induced alterations in oxidative status. |
| Databáze: | MEDLINE |
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