Potent Hepatitis C Virus NS5A Inhibitors Containing a Benzidine Core.

Autor:	Bae IH; Department of Chemistry, College of Natural Sciences, Seoul National University , Seoul 151-747, South Korea., Choi JK; Department of Chemistry, College of Natural Sciences, Seoul National University , Seoul 151-747, South Korea., Chough C; Department of Chemistry, College of Natural Sciences, Seoul National University , Seoul 151-747, South Korea., Keum SJ; Department of Life Sciences, Pohang University of Science and Technology , Pohang 790-784, South Korea., Kim H; Department of Life Sciences, Pohang University of Science and Technology , Pohang 790-784, South Korea., Jang SK; Department of Life Sciences, Pohang University of Science and Technology , Pohang 790-784, South Korea., Kim BM; Department of Chemistry, College of Natural Sciences, Seoul National University , Seoul 151-747, South Korea.
Jazyk:	angličtina
Zdroj:	ACS medicinal chemistry letters [ACS Med Chem Lett] 2013 Dec 04; Vol. 5 (3), pp. 255-8. Date of Electronic Publication: 2013 Dec 04 (Print Publication: 2014).
DOI:	10.1021/ml4003293
Abstrakt:	Here we report the discovery of a series of potent hepatitis C virus (HCV) NS5A inhibitors based on the benzidine prolinamide backbone. Taking a simple synthetic route, we developed a novel inhibitor structure, which allows easy modification, and through optimization of the capping group, we identified compound 6 with highly potent anti-HCV activity. Compound 6 is nontoxic and is anticipated to be an effective HCV drug candidate.
Databáze:	MEDLINE
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