New Peptide-based antimicrobials for tackling drug resistance in bacteria: single-cell fluorescence imaging.

Autor:	Pagès JM; UMR-MD1, Aix-Marseille Université IRBA, Faculte de Medecine, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France., Kascàkovà S; DISCO Beamline, Synchrotron Soleil , L'Orme des Merisiers, 91192 Gif-sur-Yvette, France., Maigre L; UMR-MD1, Aix-Marseille Université IRBA, Faculte de Medecine, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France., Allam A; UMR 8601, LCBPT, Université Paris Descartes , PRES Paris cité, 45 rue des Sts Pères, 75270 Paris Cedex 06, France., Alimi M; UMR 8601, LCBPT, Université Paris Descartes , PRES Paris cité, 45 rue des Sts Pères, 75270 Paris Cedex 06, France., Chevalier J; UMR-MD1, Aix-Marseille Université IRBA, Faculte de Medecine, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France., Galardon E; UMR 8601, LCBPT, Université Paris Descartes , PRES Paris cité, 45 rue des Sts Pères, 75270 Paris Cedex 06, France., Réfrégiers M; DISCO Beamline, Synchrotron Soleil , L'Orme des Merisiers, 91192 Gif-sur-Yvette, France., Artaud I; UMR 8601, LCBPT, Université Paris Descartes , PRES Paris cité, 45 rue des Sts Pères, 75270 Paris Cedex 06, France.
Jazyk:	angličtina
Zdroj:	ACS medicinal chemistry letters [ACS Med Chem Lett] 2013 May 07; Vol. 4 (6), pp. 556-9. Date of Electronic Publication: 2013 May 07 (Print Publication: 2013).
DOI:	10.1021/ml400073g
Abstrakt:	New peptide molecules with metal binding abilities proved to be active against multidrug resistant clinical isolates. One of them labeled with a dansylated lysine has been imaged inside single-multidrug resistant bacteria cells by deep ultraviolet fluorescence, showing a heterogeneous subcellular localization. The fluorescence intensity is clearly related to the accumulation of the drug inside the bacteria, being dependent both on its concentration and on the incubation time with cells.
Databáze:	MEDLINE
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