Effectiveness of an absorbable fibrin sealant patch to reduce lymphoceles formation after axillary lymphadenectomy for breast cancer: a matched-pair analysis.

Autor: Navarro-Rodríguez E; Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain. Electronic address: helenanr1@hotmail.com., Gómez-Luque I; Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain., Díaz-Jiménez N; Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain., Rioja-Torres P; Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain., Bascuñana-Estudillo G; Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain., Ruiz-Rabelo JF; Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain., Ciria-Bru R; Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain., Álvarez-Benito M; Department of Radiodiagnosis, University Hospital Reina Sofía, Córdoba, Spain., Rufián-Peña S; Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain., Briceño-Delgado J; Department of Surgery, University Hospital Reina Sofía, Córdoba, Spain.
Jazyk: angličtina
Zdroj: American journal of surgery [Am J Surg] 2014 Nov; Vol. 208 (5), pp. 824-830. Date of Electronic Publication: 2014 Apr 13.
DOI: 10.1016/j.amjsurg.2013.12.041
Abstrakt: Background: This study evaluated the use of TachoSil as an adjunctive therapy for reducing axillary lymphocele formation.
Methods: Eighty-six patients diagnosed with breast cancer N+ and treated with axillary lymphadenectomy received a TachoSil patch in the axillary wound. Using a database of patients without placing a hemostatic patch, we applied a matched case-control in a 1-to-2 fashion. Multiple and logistic regression analyses were used to evaluate postoperative results.
Results: Patient group with TachoSil showed a significantly lower drainage volume (P < .001) and the length of stay was significantly shorter (P < .001). The number of patients with evacuative punctures was 24.5% in the group with patch versus 51.2% in the control group (P < .001). In multivariate analysis, the use of TachoSil was a significant predictor of reducing axillary drainage volume (P < .001), mean length of hospital stay (P = .001), and number of evacuative punctures of lymphocele (odds ratio .264, 95% confidence interval .144 to .484, P < .001).
Conclusion: The use of TachoSil in axillary lymphadenectomy may be a safe and useful treatment option for reducing axillary drainage volume, incidence of symptomatic lymphocele, and hospital stay.
(Copyright © 2014 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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