Efficient purging of deleterious mutations in plants with haploid selfing.

Autor:	Szövényi P; Institute of Evolutionary Biology and Environmental Studies, University of Zurich, SwitzerlandInstitute of Systematic Botany, University of Zurich, SwitzerlandSwiss Institute of Bioinformatics, Quartier Sorge-Batiment Genopode, Lausanne, SwitzerlandMTA-ELTE-MTM Ecology Research Group, ELTE, Biological Institute, Hungary peter.szoevenyi@uzh.ch., Devos N; Department of Biology, Duke University., Weston DJ; Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN., Yang X; Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN., Hock Z; Institute of Systematic Botany, University of Zurich, Switzerland., Shaw JA; Department of Biology, Duke University., Shimizu KK; Institute of Evolutionary Biology and Environmental Studies, University of Zurich, Switzerland., McDaniel SF; Biology Department, University of Florida., Wagner A; Institute of Evolutionary Biology and Environmental Studies, University of Zurich, SwitzerlandSwiss Institute of Bioinformatics, Quartier Sorge-Batiment Genopode, Lausanne, SwitzerlandBioinformatics Institute, Agency for Science, Technology and Research (A*STAR), SingaporeThe Santa Fe Institute, Santa Fe NM.
Jazyk:	angličtina
Zdroj:	Genome biology and evolution [Genome Biol Evol] 2014 May 14; Vol. 6 (5), pp. 1238-52. Date of Electronic Publication: 2014 May 14.
DOI:	10.1093/gbe/evu099
Abstrakt:	In diploid organisms, selfing reduces the efficiency of selection in removing deleterious mutations from a population. This need not be the case for all organisms. Some plants, for example, undergo an extreme form of selfing known as intragametophytic selfing, which immediately exposes all recessive deleterious mutations in a parental genome to selective purging. Here, we ask how effectively deleterious mutations are removed from such plants. Specifically, we study the extent to which deleterious mutations accumulate in a predominantly selfing and a predominantly outcrossing pair of moss species, using genome-wide transcriptome data. We find that the selfing species purge significantly more nonsynonymous mutations, as well as a greater proportion of radical amino acid changes which alter physicochemical properties of amino acids. Moreover, their purging of deleterious mutation is especially strong in conserved regions of protein-coding genes. Our observations show that selfing need not impede but can even accelerate the removal of deleterious mutations, and do so on a genome-wide scale. (© The Author(s) 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.)
Databáze:	MEDLINE
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