Evaluation of the QuEChERS method for the extraction of pharmaceuticals and personal care products from drinking-water treatment sludge with determination by UPLC-ESI-MS/MS.

Autor: Cerqueira MBR; Post-Graduation Program in Technological and Environmental Chemistry, Escola de Química e Alimentos, Laboratório de Análise de Compostos Orgânicos e Metais (LACOM), Universidade Federal do Rio Grande, Av Itália, km 8, s/n, Rio Grande, Rio Grande do Sul State 96201-900, Brazil., Guilherme JR; Post-Graduation Program in Technological and Environmental Chemistry, Escola de Química e Alimentos, Laboratório de Análise de Compostos Orgânicos e Metais (LACOM), Universidade Federal do Rio Grande, Av Itália, km 8, s/n, Rio Grande, Rio Grande do Sul State 96201-900, Brazil., Caldas SS; Post-Graduation Program in Technological and Environmental Chemistry, Escola de Química e Alimentos, Laboratório de Análise de Compostos Orgânicos e Metais (LACOM), Universidade Federal do Rio Grande, Av Itália, km 8, s/n, Rio Grande, Rio Grande do Sul State 96201-900, Brazil., Martins ML; Laboratório de Análises de Resíduos de Pesticidas (LARP), Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul State, Brazil., Zanella R; Laboratório de Análises de Resíduos de Pesticidas (LARP), Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul State, Brazil., Primel EG; Post-Graduation Program in Technological and Environmental Chemistry, Escola de Química e Alimentos, Laboratório de Análise de Compostos Orgânicos e Metais (LACOM), Universidade Federal do Rio Grande, Av Itália, km 8, s/n, Rio Grande, Rio Grande do Sul State 96201-900, Brazil. Electronic address: dqmednei@furg.br.
Jazyk: angličtina
Zdroj: Chemosphere [Chemosphere] 2014 Jul; Vol. 107, pp. 74-82. Date of Electronic Publication: 2014 Apr 12.
DOI: 10.1016/j.chemosphere.2014.03.026
Abstrakt: A modified version of the QuEChERS method has been evaluated for the determination of 21 pharmaceuticals and 6 personal care products (PPCPs) in drinking-water sludge samples by employing ultra high liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The performance of the method was evaluated through linearity, recovery, precision (intra-day), method detection and quantification limits (MDL and MQL) and matrix effect. The calibration curves prepared in acetonitrile and in the matrix extract showed a correlation coefficient ranging from 0.98 to 0.99. MQLs values were on the ng g(-1) order of magnitude for most compounds. Recoveries between 50% and 93% were reached with RSDs lower than 10% for most compounds. Matrix effect was almost absent with values lower than 16% for 93% of the compounds. By coupling a quick and simple extraction called QuEChERS with the UPLC-MS/MS analysis, a method that is both selective and sensitive was obtained. This methodology was successfully applied to real samples and caffeine and benzophenone-3 were detected in ng g(-1) levels.
(Copyright © 2014 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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