[Degenerative and regenerative changes in hippocampus in postnatal ontogenesis].
| Autor: | Zimushkina NA, Kosareva PV, Cherkasova VG, Khorinko VP |
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| Jazyk: | ruština |
| Zdroj: | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2014; Vol. 114 (4), pp. 73-7. |
| Abstrakt: | Objectives: To study the degenerative and regenerative age-related changes in human hippocampus. Materials and Methods: An immunohistochemical investigation of the hippocampus was carried out in 50 people, aged 25-89 years, who died for different reasons not connected with the cerebral injury or pathology. Expression of the following markers was determined: tau-protein, GFAP, CD105/endoglin, E-selectin, NCAM, Cdk2. Statistical analysis was performed with the program package Biostat. Results and Conclusions: Gliogenesis and vasculogenesis processes were active in old and very old age. They may be conditioned by ischemic cerebral injuries and accompany the development of Alzheimer's disease. |
| Databáze: | MEDLINE |
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