A case-control study of the role of human papillomavirus in oesophageal squamous cell carcinoma in australia.

Autor: Liyanage SS; School of Public Health and Community Medicine, The University of New South Wales, Kensington, NSW 2052, Australia., Segelov E; Department of Medicine, St. Vincent's Hospital Clinical School, The University of New South Wales, Kensington, NSW 2052, Australia., Malik A; UNSW Medicine, The University of New South Wales, Kensington, NSW 2052, Australia., Garland SM; Department of Microbiology and Infectious Diseases, The Royal Women's Hospital, Parkville, VIC 3052, Australia ; Department of Obstetrics and Gynecology, Murdoch Children's Research Institute, University of Melbourne, Parkville, VIC 3010, Australia., Tabrizi SN; Department of Microbiology and Infectious Diseases, The Royal Women's Hospital, Parkville, VIC 3052, Australia ; Department of Obstetrics and Gynecology, Murdoch Children's Research Institute, University of Melbourne, Parkville, VIC 3010, Australia., Cummins E; Department of Microbiology and Infectious Diseases, The Royal Women's Hospital, Parkville, VIC 3052, Australia ; Department of Obstetrics and Gynecology, Murdoch Children's Research Institute, University of Melbourne, Parkville, VIC 3010, Australia., Seale H; School of Public Health and Community Medicine, The University of New South Wales, Kensington, NSW 2052, Australia., Rahman B; School of Public Health and Community Medicine, The University of New South Wales, Kensington, NSW 2052, Australia., Moa A; School of Public Health and Community Medicine, The University of New South Wales, Kensington, NSW 2052, Australia., Barbour AP; Department of Surgery, Princess Alexandra Hospital, The University of Queensland, St Lucia, QLD 4072, Australia., Crowe PJ; Department of Surgery, Prince of Wales Hospital Clinical School, The University of New South Wales, Kensington, NSW 2052, Australia., MacIntyre CR; School of Public Health and Community Medicine, The University of New South Wales, Kensington, NSW 2052, Australia.
Jazyk: angličtina
Zdroj: Journal of oncology [J Oncol] 2014; Vol. 2014, pp. 236482. Date of Electronic Publication: 2014 Apr 28.
DOI: 10.1155/2014/236482
Abstrakt: Objective. We investigate the prevalence of human papillomavirus (HPV) in oesophageal squamous cell carcinoma (OSCC) tissues compared to oesophageal tissue from healthy controls, in an Australian cohort. Methods. We conducted a hospital-based case-control study of 99 patients with OSCC and 100 healthy controls to examine the presence of HPV DNA. Paraffin tissues were tested using the PapType high-risk HPV detection and genotyping kit and with INNO-LiPA HPV Genotyping Extra. The biopsy samples were tested for HPV using a PCR-ELISA method based on the L1 consensus primer set PGMY09-PGMY11. Results. HPV DNA of the oncogenic genotype 16 was detected in 1/99 case specimens, a rate of 1010 per 100,000 (95% CI: 30-5500). All control specimens were negative for HPV. Significantly higher rates of smoking, other aerodigestive cancers, and mortality were seen among cases than controls. A pooled analysis of this study and the only other Australian case-control study found that 9/321 cases and 0/155 controls were positive for HPV. The pooled odds ratio for HPV being a risk factor for OSCC was 9.35 (95% CI: 0.47-190.33). Conclusion. Our results suggest that in this multifactorial cancer HPV may be an additional risk factor; although a larger, better powered study is needed.
Databáze: MEDLINE
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