| Autor: |
Modvig A; The Center for Insoluble Protein Structures (inSPIN), Department of Chemistry and the Interdisciplinary Nanoscience Center, Aarhus University , Gustav Wieds Vej 14, 8000 Aarhus, Denmark., Andersen TL, Taaning RH, Lindhardt AT, Skrydstrup T |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of organic chemistry [J Org Chem] 2014 Jun 20; Vol. 79 (12), pp. 5861-8. Date of Electronic Publication: 2014 Jun 11. |
| DOI: |
10.1021/jo500801t |
| Abstrakt: |
Hydrogen and deuterium gas were produced and directly applied in a two-chamber system. These gaseous reagents were generated by the simple reaction of metallic zinc with HCl in water for H2 and DCl in deuterated water for D2. The setup proved efficient in classical Pd-catalyzed reductions of ketones, alkynes, alkenes, etc. in near-quantitative yields. The method was extended to the synthesis and isotope labeling of quinoline and 1,2,3,4-tetrahydroquinoline derivatives. Finally, CX-546 and Olaparib underwent efficient Ir-catalyzed hydrogen isotope exchange reactions. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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