| Autor: |
Besnard T; Unité Fonctionnelle de Toxicologie, Laboratoire de Biochimie et de Biologie Moléculaire, CHRU de Lille-59037 Lille Cedex., Sadeg N, Ricart N, Richecœur J, Nisse P, Vinner E, Houdret N, Humbert L, Lhermitte M |
| Jazyk: |
angličtina |
| Zdroj: |
Acta clinica Belgica [Acta Clin Belg] 2002; Vol. 57 Suppl 1, pp. 8-11. |
| DOI: |
10.1179/acb.2002.069 |
| Abstrakt: |
Crimidine (2 chloro, 4 methyl, 6 dimethyl amidopyrine) is a synthetic rodenticide which causes acute poisonings after oral ingestion in human. Major toxic effects are consciousness disorders, hypertonic coma and convulsions. Toxic level in human is about 5 mg/Kg. An intoxication case is reported. Five serums collected at different times were analyzed with HPLC/ ES/MS. Crimidine was extracted with ethylacetate with recovery over 80 %. Linearity was up to 800 μg/L. LOQ and LOD were 0.5 and 0.3 μg/L respectively. The coefficients of variation were less than 10 % for repeatability and reproductibility. Serum levels varied from 368 μg/L for H0 to 64 μg/L for H10 and elimination of crimidine was linear in time. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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