Serum cotinine and whole blood folate concentrations in pregnancy.

Autor: Prasodjo A; Department of Epidemiology, Brown University School of Public Health, Providence, RI., Pfeiffer CM; Division of Laboratory Sciences, National Center for Environmental Health, Nutritional Biomarkers Branch, Centers for Disease Control and Prevention, Atlanta, GA., Fazili Z; Division of Laboratory Sciences, National Center for Environmental Health, Nutritional Biomarkers Branch, Centers for Disease Control and Prevention, Atlanta, GA., Xu Y; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH., Liddy S; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH., Yolton K; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH., Savitz DA; Department of Epidemiology, Brown University School of Public Health, Providence, RI., Lanphear BP; Faculty of Health and Sciences, Simon Fraser University, Burnaby, Canada; Child and Family Research Institute, BC Children's and Women's Hospital, Vancouver, Canada., Braun JM; Department of Epidemiology, Brown University School of Public Health, Providence, RI. Electronic address: joseph_braun_1@brown.edu.
Jazyk: angličtina
Zdroj: Annals of epidemiology [Ann Epidemiol] 2014 Jul; Vol. 24 (7), pp. 498-503.e1. Date of Electronic Publication: 2014 Apr 24.
DOI: 10.1016/j.annepidem.2014.04.004
Abstrakt: Purpose: Prenatal tobacco smoke exposure may be associated with low maternal folate levels that increase the risk of adverse infant and child health outcomes by reducing folate availability during fetal development.
Methods: Using data from the Health Outcomes and Measures of the Environment Study, we examined the relationship between secondhand or active tobacco smoke exposure and whole blood folate concentrations in pregnant women from Cincinnati, Ohio (n = 362) at approximately 16-week gestation. We used multivariable linear regression to examine the association between continuous or categorical serum cotinine levels and whole blood folate levels, adjusting for sociodemographic, dietary, and perinatal variables.
Results: After adjustment for potential confounders, an interquartile range increases in serum cotinine concentration (0.012-0.224 ng/mL) was suggestively associated with decreased whole blood folate levels (β, -23 nmol/L; 95% confidence interval (CI), -49, 3; P value = .08). Compared with unexposed women, reductions in mean whole blood folate were observed among active smokers (β, -94, 95% CI, 195, 6 nmol/L; P value = .40); smaller reductions were observed among women with secondhand exposure (β, 26; CI, 84, 32 nmol/L; P value = .07).
Conclusions: Consistent with prior studies, active smoking was associated with reduced whole blood folate levels among these pregnant women. Secondhand tobacco smoke exposures were associated with small and imprecise reductions in whole blood folate levels.
(Copyright © 2014 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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