Weight change therapy as a potential treatment for end-stage ovarian carcinoma.

Autor:	Oshakbayev KP; Department of Oncology, Republican Scientific Center for Emergency Medicine, Astana, Republic of Kazakhstan., Alibek K; Department of Oncology, Republican Scientific Center for Emergency Medicine, Astana, Republic of Kazakhstan., Ponomarev IO; Department of Oncology, Republican Scientific Center for Emergency Medicine, Astana, Republic of Kazakhstan., Uderbayev NN; Department of Surgery, Republican Scientific Center for Emergency Care, Astana, Republic of Kazakhstan., Dukenbayeva BA; Department of Pathology, Astana Medical University, Astana, Republic of Kazakhstan.
Jazyk:	angličtina
Zdroj:	The American journal of case reports [Am J Case Rep] 2014 May 12; Vol. 15, pp. 203-11. Date of Electronic Publication: 2014 May 12 (Print Publication: 2014).
DOI:	10.12659/AJCR.890229
Abstrakt:	Patient: Female, 41 FINAL DIAGNOSIS: Ovarian carcinoma Symptoms: Ascites • hepatomegaly • weight loss Medication: - Clinical Procedure: - Specialty: Oncology. Objective: Unusual or unexpected effect of treatment. Background: The aim of this case report is to present the results of treatment of end-stage ovarian carcinoma in a 41-year-old women using weight loss therapy. Case Report: We describe the case of a female aged 41 years with epithelial invasive ovarian cancer of III-IV stage, T3N2M1. Concurrent diseases were: abdominal carcinomatosis; hepatomegaly; ascites; condition after laparocentesis and skin-abdominal fistula; condition after 6 courses of neo-adjuvant polychemotherapy; hypertension II stage, risk factor of 3-4; dyslipidemia; and metabolic syndrome. A weight loss method based on a very-low-calorie diet and physical activity was used. Body weight was reduced from 74 kg to 53 due to loss of adipose tissue after 6 months of therapy. At the same time, the percentages of water and muscle tissue were increased significantly. While overweight was reducing, clinical, laboratory, and instrumental results were improving. As a result of the weight loss therapy, about ≈100 mm-sized ovarian cancer was transformed into smaller-sized ovarian cysts. Conclusions: An analgesic effect was also achieved without use of narcotic or non-narcotic analgesics. These cyto-reversible processes were documented by laboratory and instrumental data. The mechanisms behind these differences remain to be elucidated. Future research with a larger study cohort and longer follow-up is needed to further investigate the role of caloric restriction diet in cancer cell changes in ovarian cancer.
Databáze:	MEDLINE
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