Oncolytic virotherapy of canine and feline cancer.
| Autor: | Gentschev I; Department of Biochemistry, University of Wuerzburg, Wuerzburg D-97074, Germany. ivaylo.gentschev@mail.uni-wuerzburg.de., Patil SS; Department of Biochemistry, University of Wuerzburg, Wuerzburg D-97074, Germany. sandeep.patil@stud-mail.uni-wuerzburg.de., Petrov I; Department of Biochemistry, University of Wuerzburg, Wuerzburg D-97074, Germany. ivan.petrov@uni-wuerzburg.de., Cappello J; Genelux Corporation, San Diego Science Center, San Diego, CA 92109, USA. Joseph.Cappello@genelux.com., Adelfinger M; Department of Biochemistry, University of Wuerzburg, Wuerzburg D-97074, Germany. marion.adelfinger@biozentrum.uni-wuerzburg.de., Szalay AA; Department of Biochemistry, University of Wuerzburg, Wuerzburg D-97074, Germany. aaszalay@genelux.com. |
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| Jazyk: | angličtina |
| Zdroj: | Viruses [Viruses] 2014 May 16; Vol. 6 (5), pp. 2122-37. Date of Electronic Publication: 2014 May 16. |
| DOI: | 10.3390/v6052122 |
| Abstrakt: | Cancer is the leading cause of disease-related death in companion animals such as dogs and cats. Despite recent progress in the diagnosis and treatment of advanced canine and feline cancer, overall patient treatment outcome has not been substantially improved. Virotherapy using oncolytic viruses is one promising new strategy for cancer therapy. Oncolytic viruses (OVs) preferentially infect and lyse cancer cells, without causing excessive damage to surrounding healthy tissue, and initiate tumor-specific immunity. The current review describes the use of different oncolytic viruses for cancer therapy and their application to canine and feline cancer. |
| Databáze: | MEDLINE |
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