Sleep deprivation impairs the extinction of cocaine-induced environmental conditioning in mice.

Autor: Berro LF; Department of Psychobiology, Universidade Federal de São Paulo, Brazil., Hollais AW; Department of Pharmacology, Universidade Federal de São Paulo, Brazil., Patti CL; Department of Psychobiology, Universidade Federal de São Paulo, Brazil., Fukushiro DF; Department of Pharmacology, Universidade Federal de São Paulo, Brazil., Mári-Kawamoto E; Department of Pharmacology, Universidade Federal de São Paulo, Brazil., Talhati F; Department of Pharmacology, Universidade Federal de São Paulo, Brazil., Costa JM; Department of Pharmacology, Universidade Federal de São Paulo, Brazil., Zanin KA; Department of Psychobiology, Universidade Federal de São Paulo, Brazil., Lopes-Silva LB; Department of Psychobiology, Universidade Federal de São Paulo, Brazil., Ceccon LM; Department of Pharmacology, Universidade Federal de São Paulo, Brazil., Santos R; Department of Pharmacology, Universidade Federal de São Paulo, Brazil., Procópio-Souza R; Department of Pharmacology, Universidade Federal de São Paulo, Brazil., Trombin TF; Department of Pharmacology, Universidade Federal de São Paulo, Brazil., Yokoyama TS; Department of Pharmacology, Universidade Federal de São Paulo, Brazil., Wuo-Silva R; Department of Pharmacology, Universidade Federal de São Paulo, Brazil., Tufik S; Department of Psychobiology, Universidade Federal de São Paulo, Brazil., Andersen ML; Department of Psychobiology, Universidade Federal de São Paulo, Brazil. Electronic address: ml.andersen12@gmail.com., Frussa-Filho R; Department of Psychobiology, Universidade Federal de São Paulo, Brazil; Department of Pharmacology, Universidade Federal de São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2014 Sep; Vol. 124, pp. 13-8. Date of Electronic Publication: 2014 May 13.
DOI: 10.1016/j.pbb.2014.05.001
Abstrakt: Persistence of a drug-environment conditioning induced by repeated psychostimulant treatment is thought to play a key role in the addictive cycle. In addition, sleep disorders are a common feature in patients with addictive disorders. Sleep deprivation shares similar neurobiological effects with psychostimulants. Therefore, we investigated whether sleep deprivation would impair the extinction of previously established conditioning between the drug effect and the environmental cues. Four cohorts of male adult mice underwent a behavioral sensitization procedure pairing drug (cocaine at 15 mg/kg, i.p.) or saline with environment (open-field apparatus). The extinction of conditioned locomotion was evaluated after control (home-cage maintained) or sleep deprivation (gentle handling method for 6h) conditions. Sleep deprivation both postponed the initiation and impaired the completeness of extinction of the conditioned locomotion promoted by previous drug-environment conditioning in cocaine-sensitized animals. While the cocaine control group required 5 free-drug sessions of exposure to the open-field apparatus to complete extinction of conditioned locomotion, the cocaine pre-treated group that experienced sleep deprivation before each extinction session still significantly differed from its respective control group on Day 5 of extinction. The possibility that the sleep condition can influence the extinction of a long-lasting association between drug effects and environmental cues can represent new outcomes for clinically relevant phenomena.
(Copyright © 2014 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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