Divergent picobirnaviruses in human feces.
| Autor: | Ng TF; terryfeifan@gmail.com delwarte@medicine.ucsf.edu., Vega E; National Calicivirus Laboratory, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Kondov NO; Blood Systems Research Institute, San Francisco, California, USA., Markey C; Blood Systems Research Institute, San Francisco, California, USA., Deng X, Gregoricus N; National Calicivirus Laboratory, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Vinjé J; National Calicivirus Laboratory, Centers for Disease Control and Prevention, Atlanta, Georgia, USA., Delwart E; terryfeifan@gmail.com delwarte@medicine.ucsf.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Genome announcements [Genome Announc] 2014 May 15; Vol. 2 (3). Date of Electronic Publication: 2014 May 15. |
| DOI: | 10.1128/genomeA.00415-14 |
| Abstrakt: | The near-complete genomes of two picobirnaviruses (PBVs) in diarrheal stool samples, human picobirnaviruses D and E (HuPBV-D and -E), were genetically characterized. Their RNA-dependent RNA polymerase (RdRp) protein sequences had <66% identities to known PBVs. Due to a single nucleotide insertion, the open reading frame 2 (ORF2) in segment 1 of HuPBV-D was interrupted by a stop codon. A small stem-loop structure overlying the stop codon may result in translational readthrough into the rest of ORF2. (Copyright © 2014 Ng et al.) |
| Databáze: | MEDLINE |
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