From chip-in-a-lab to lab-on-a-chip: towards a single handheld electronic system for multiple application-specific lab-on-a-chip (ASLOC).

Autor: Neužil P; KIST Europe Forschungsgesellschaft mbH, Campus E7 1, DE-66 123 Saarbrücken, Germany. pavel.neuzil@gmail.com., Campos CD, Wong CC, Soon JB, Reboud J, Manz A
Jazyk: angličtina
Zdroj: Lab on a chip [Lab Chip] 2014 Jul 07; Vol. 14 (13), pp. 2168-76.
DOI: 10.1039/c4lc00310a
Abstrakt: We present a portable, battery-operated and application-specific lab-on-a-chip (ASLOC) system that can be easily configured for a wide range of lab-on-a-chip applications. It is based on multiplexed electrical current detection that serves as the sensing system. We demonstrate different configurations to perform most detection schemes currently in use in LOC systems, including some of the most advanced such as nanowire-based biosensing, surface plasmon resonance sensing, electrochemical detection and real-time PCR. The complete system is controlled by a single chip and the collected information is stored in situ, with the option of transferring the data to an external display by using a USB interface. In addition to providing a framework for truly portable real-life developments of LOC systems, we envisage that this system will have a significant impact on education, especially since it can easily demonstrate the benefits of integrated microanalytical systems.
Databáze: MEDLINE