Low pepsinogen I level predicts multiple gastric epithelial neoplasias for endoscopic resection.

Autor: Park SY; Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea., Lim SO; Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea., Ki HS; Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea., Jun CH; Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea., Park CH; Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea., Kim HS; Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea., Choi SK; Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea., Rew JS; Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.
Jazyk: angličtina
Zdroj: Gut and liver [Gut Liver] 2014 May; Vol. 8 (3), pp. 277-81.
DOI: 10.5009/gnl.2014.8.3.277
Abstrakt: Background/aims: Synchronous/metachronous gastric epithelial neoplasias (GENs) in the remaining lesion can develop at sites other than the site of endoscopic resection. In the present study, we aimed to investigate the predictive value of serum pepsinogen for detecting multiple GENs in patients who underwent endoscopic resection.
Methods: In total, 228 patients with GEN who underwent endoscopic resection and blood collection for pepsinogen I and II determination were evaluated retrospectively.
Results: The mean period of endoscopic follow-up was 748.8±34.7 days. Synchronous GENs developed in 46 of 228 (20.1%) and metachronous GENs in 27 of 228 (10.6%) patients during the follow-up period. Multiple GENs were associated with the presence of pepsinogen I <30 ng/mL (p<0.001). Synchronous GENs were associated with the presence of pepsinogen I <30 ng/mL (p<0.001).
Conclusions: Low pepsinogen I levels predict multiple GENs after endoscopic resection, especially synchronous GENs. Cautious endoscopic examination prior to endoscopic resection to detect multiple GENs should be performed for these patients.
Databáze: MEDLINE
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