Emergence of Multidrug Resistant Extended-Spectrum β-Lactamase Producing Eshcherichia coli Associated With Urinary Tract Infections in Bangladesh.

Autor: Mowla R; Deptartment of Clinical Pharmacy & Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh., Imam KM; Deptartment of Clinical Pharmacy & Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh., Asaduzzaman M; Deptartment of Clinical Pharmacy & Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh., Nasrin N; Deptartment of Pharmacy, East West University, Dhaka-1212, Bangladesh., Raihan SZ; Deptartment of Clinical Pharmacy & Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh., Chowdhury AK; Deptartment of Clinical Pharmacy & Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh.
Jazyk: angličtina
Zdroj: Journal of basic and clinical pharmacy [J Basic Clin Pharm] 2011 Dec; Vol. 3 (1), pp. 225-8. Date of Electronic Publication: 2012 Feb 15.
DOI: 10.4103/0976-0105.103829
Abstrakt: The incidence of infections due to extended-spectrum β-lactamase (ESBL)-producing Escherichia coli has been increased dramatically in recent years. Treatment is difficult because of frequent multidrug resistance. To identify the sensitivity of commonly used antibiotics, 36 ESBL producing E. coli strains were isolated from young adult female patients in a govt. medical college hospital in Bangladesh. The samples were studied for antimicrobial sensitivity against nine (9) commonly used antibiotics namely ampicillin (amp), trimethoprim-sulfomethoxazole (tms), tetracycline (tet), ciprofloxacin (cip), mecillinum (mel), ceftriaxone (cef), nalidixic acid (nal), Azithromycin (azm) and Chloramphenicol (chl) and the MIC values were determined by agar dilution method. Overall, 72% of the strains were multidrug resistant (MDR) i.e. resistant to two or more drugs. Among 36 strains, 14 isolates were initially found to be resistant against third generation cephalosporin, ceftriaxone. Those were subjected to the test for production of ESBL (Extended Spectrum β-Lactamase) and 7 showed positive results.
Databáze: MEDLINE