Atherosclerosis, some serum inflammatory markers in psoriasis.
| Autor: | Alpsoy S; Department of Cardiology, Faculty of Medicine Namık Kemal University, Tekirdag, Turkey - serefalpsoy@hotmail.com., Akyuz A, Erfan G, Akkoyun DC, Topcu B, Guzel S, Kaya S, Kulac M |
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| Jazyk: | angličtina |
| Zdroj: | Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia [G Ital Dermatol Venereol] 2014 Apr; Vol. 149 (2), pp. 167-75. |
| Abstrakt: | Aim: Psoriasis is an autoimmune inflammatory disease which is associated with increased inflammatory markers and atherosclerosis. We wanted to investigate whether there is a relationship between some inflammatory markers and subclinical atherosclerosis markers. Methods: We studied 60 psoriasis patients and 50 healthy controls. Demographic, biochemical parameters, C3, C4, d-dimer, CRP, fibrinogen and YKL-40 (human cartilage glycoprotein-39) levels were measured. After measuring carotid intima-media thickness (cIMT) and aortic elasticity parameters such as aortic strain, (beta) stiffness index and compliance, statistical comparisons were done. Results: Patients with psoriasis had significantly higher diastolic blood pressure, CRP, fibrinogen, C3, uric acid levels, β-stiffness index, and cIMT values than the control group. cIMT was correlated with CRP, YKL-40 and psoriasis area and severity index (PASI) score (r=0.219, P=0.038; r=0.225, P=0.033 and r=0.275, P=0.034). Aortic strain (%), aortic compliance and aortic stiffness index were correlated with C3 (r=-0.349, r=-0.526 and r=0.235) and fibrinogen (r=-0.354, r=-0.275 and r=0.289), all P values <0.05, but not with PASI score. The presence of psoriasis was related to aortic strain (β±SE: -2.055±0.861, P=0.019) and β-stiffness index (β±SE: 2.934±1.143, P=0.012). Conclusion: Serum C3, CRP, fibrinogen and YKL-40 levels are elevated as well as increased cIMT and impaired aortic elasticity in psoriasis. CRP, YKL-40 and PASI score are correlated with cIMT. Increased serum C3 and fibrinogen levels correlate negatively with aortic strain and aortic compliance, and correlate positively with the β-stiffness index. |
| Databáze: | MEDLINE |
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