A proliferative burst during preadolescence establishes the final cardiomyocyte number.

Autor:	Naqvi N; Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA., Li M; Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia., Calvert JW; Division of Cardiothoracic Surgery, Department of Surgery, Carlyle Fraser Heart Center, Emory University School of Medicine, Atlanta, GA 30308, USA., Tejada T; Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA., Lambert JP; Division of Cardiothoracic Surgery, Department of Surgery, Carlyle Fraser Heart Center, Emory University School of Medicine, Atlanta, GA 30308, USA., Wu J; Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia., Kesteven SH; Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia., Holman SR; Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia., Matsuda T; Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA., Lovelock JD; Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA., Howard WW; Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA., Iismaa SE; Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia; University of New South Wales, Kensington, NSW 2033, Australia., Chan AY; Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia., Crawford BH; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA; Center for Cardiovascular Biology, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA., Wagner MB; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA; Center for Cardiovascular Biology, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA., Martin DI; Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA., Lefer DJ; Division of Cardiothoracic Surgery, Department of Surgery, Carlyle Fraser Heart Center, Emory University School of Medicine, Atlanta, GA 30308, USA., Graham RM; Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia; University of New South Wales, Kensington, NSW 2033, Australia. Electronic address: b.graham@victorchang.edu.au., Husain A; Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address: ahusai2@emory.edu.
Jazyk:	angličtina
Zdroj:	Cell [Cell] 2014 May 08; Vol. 157 (4), pp. 795-807.
DOI:	10.1016/j.cell.2014.03.035
Abstrakt:	It is widely believed that perinatal cardiomyocyte terminal differentiation blocks cytokinesis, thereby causing binucleation and limiting regenerative repair after injury. This suggests that heart growth should occur entirely by cardiomyocyte hypertrophy during preadolescence when, in mice, cardiac mass increases many-fold over a few weeks. Here, we show that a thyroid hormone surge activates the IGF-1/IGF-1-R/Akt pathway on postnatal day 15 and initiates a brief but intense proliferative burst of predominantly binuclear cardiomyocytes. This proliferation increases cardiomyocyte numbers by ~40%, causing a major disparity between heart and cardiomyocyte growth. Also, the response to cardiac injury at postnatal day 15 is intermediate between that observed at postnatal days 2 and 21, further suggesting persistence of cardiomyocyte proliferative capacity beyond the perinatal period. If replicated in humans, this may allow novel regenerative therapies for heart diseases. (Copyright © 2014 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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