Study of pharmacological activities of methanol extract of Jatropha gossypifolia fruits.

Autor:	Apu AS; Department of Pharmacy, East West University, Jahurul Islam City, Aftabnagar, Dhaka, Bangladesh., Hossain F; Department of Pharmacy, East West University, Jahurul Islam City, Aftabnagar, Dhaka, Bangladesh., Rizwan F; Department of Pharmacy, East West University, Jahurul Islam City, Aftabnagar, Dhaka, Bangladesh., Bhuyan SH; Department of Pharmacy, East West University, Jahurul Islam City, Aftabnagar, Dhaka, Bangladesh., Matin M; Department of Pharmacy, East West University, Jahurul Islam City, Aftabnagar, Dhaka, Bangladesh., Jamaluddin AT; Department of Pharmacy, East West University, Jahurul Islam City, Aftabnagar, Dhaka, Bangladesh.
Jazyk:	angličtina
Zdroj:	Journal of basic and clinical pharmacy [J Basic Clin Pharm] 2012 Dec; Vol. 4 (1), pp. 20-4.
DOI:	10.4103/0976-0105.109404
Abstrakt:	Objective: The present study was carried out to investigate the possible in vivo analgesic, neuropharmacological and anti-diarrheal activities of the methanol extract of Jatropha gossypifolia fruits. Materials and Methods: The analgesic activity was measured by acetic acid induced writhing inhibition test. The neuropharmacological activities were evaluated by hole cross, hole-board, and elevated plus-maze (EPM) tests and the anti-diarrheal activity was assessed by castor oil induced diarrhea inhibition method. Findings: The extract showed highly significant (P < 0.001) analgesic activity with % inhibitions of writhing response at doses 200 and 400 mg/kg body weight were 77.86% and 71.25%, respectively. The extract at both doses showed significant (P < 0.05) sedative effect in-hole cross test. In-hole board test, the extract showed highly significant (P < 0.001) anxiolytic activity at lower dose whereas this activity was observed at higher dose in EPM test. The extract also showed highly significant (P < 0.001) anti-diarrheal activity. Conclusion: The findings of the study clearly indicate the presence of significant analgesic, neuropharmacological and anti-diarrheal properties of the plant, which demands further investigation including, compound isolation.
Databáze:	MEDLINE
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