Endothelial function, antioxidant status and vascular compliance in newly diagnosed HFE C282Y homozygotes.

Autor: Cash WJ; Department of Hepatology (Liver Unit), Royal Victoria Hospital, Belfast, UK. Electronic address: Johnny.cash@belfasttrust.hscni.net., O'Neill S; Department of Vascular and Endovascular Surgery, Royal Victoria Hospital, Belfast, UK., O'Donnell ME; Department of Vascular and Endovascular Surgery, Royal Victoria Hospital, Belfast, UK., McCance DR; Department of Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, UK., Young IS; Department of Clinical Biochemistry, Royal Victoria Hospital, Belfast, UK; Department of Medicine, Queen's University Belfast, Belfast, UK., McEneny J; Department of Medicine, Queen's University Belfast, Belfast, UK., McDougall NI; Department of Hepatology (Liver Unit), Royal Victoria Hospital, Belfast, UK., Callender ME; Department of Hepatology (Liver Unit), Royal Victoria Hospital, Belfast, UK.
Jazyk: angličtina
Zdroj: Advances in medical sciences [Adv Med Sci] 2014 Mar; Vol. 59 (1), pp. 28-33. Date of Electronic Publication: 2014 Mar 15.
DOI: 10.1016/j.advms.2013.07.001
Abstrakt: Purpose: This pilot study was aimed to establish techniques for assessing and observing trends in endothelial function, antioxidant status and vascular compliance in newly diagnosed HFE haemochromatosis during the first year of venesection.
Patients/methods: Untreated newly diagnosed HFE haemochromatosis patients were tested for baseline liver function, iron indices, lipid profile, markers of endothelial function, anti-oxidant status and vascular compliance. Following baseline assessment, subjects attended at 6-weeks and at 3, 6, 9 and 12-months for follow-up studies.
Results: Ten patients were recruited (M=8, F=2, mean age=51 years). Venesection significantly increased high density lipoproteins at 12-months (1.25 mmol/L vs. 1.37 mmol/L, p=0.01). However, venesection did not significantly affect lipid hydroperoxides, intracellular and vascular cell adhesion molecules or high sensitivity C-reactive protein (0.57 μmol/L vs. 0.51 μmol/L, p=0.45, 427.4 ng/ml vs. 307.22 ng/ml, p=0.54, 517.70 ng/ml vs. 377.50 ng/ml, p=0.51 and 290.75 μg/dL vs. 224.26 μg/dL, p=0.25). There was also no significant effect of venesection on anti-oxidant status or pulse wave velocity (9.65 m/s vs. 8.74 m/s, p=0.34).
Conclusions: Venesection significantly reduced high density lipoproteins but was not associated with significant changes in endothelial function, anti-oxidant status or vascular compliance. Larger studies using this established methodology are required to clarify this relationship further.
(Copyright © 2014 Medical University of Bialystok. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.)
Databáze: MEDLINE
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