Mirin: identifying microRNA regulatory modules in protein-protein interaction networks.

Autor:	Yang KC; Institute of Biomedical Informatics, Center for Systems and Synthetic Biology, National Yang-Ming University, Taipei 112, Department of Life Science, Graduate Institute of Biomedical Electronics and Bioinformatics and Institute of Molecular and Cellular Biology, National Taiwan University, Taipei 106, Taiwan., Hsu CL; Institute of Biomedical Informatics, Center for Systems and Synthetic Biology, National Yang-Ming University, Taipei 112, Department of Life Science, Graduate Institute of Biomedical Electronics and Bioinformatics and Institute of Molecular and Cellular Biology, National Taiwan University, Taipei 106, Taiwan., Lin CC; Institute of Biomedical Informatics, Center for Systems and Synthetic Biology, National Yang-Ming University, Taipei 112, Department of Life Science, Graduate Institute of Biomedical Electronics and Bioinformatics and Institute of Molecular and Cellular Biology, National Taiwan University, Taipei 106, Taiwan Institute of Biomedical Informatics, Center for Systems and Synthetic Biology, National Yang-Ming University, Taipei 112, Department of Life Science, Graduate Institute of Biomedical Electronics and Bioinformatics and Institute of Molecular and Cellular Biology, National Taiwan University, Taipei 106, Taiwan., Juan HF; Institute of Biomedical Informatics, Center for Systems and Synthetic Biology, National Yang-Ming University, Taipei 112, Department of Life Science, Graduate Institute of Biomedical Electronics and Bioinformatics and Institute of Molecular and Cellular Biology, National Taiwan University, Taipei 106, Taiwan Institute of Biomedical Informatics, Center for Systems and Synthetic Biology, National Yang-Ming University, Taipei 112, Department of Life Science, Graduate Institute of Biomedical Electronics and Bioinformatics and Institute of Molecular and Cellular Biology, National Taiwan University, Taipei 106, Taiwan Institute of Biomedical Informatics, Center for Systems and Synthetic Biology, National Yang-Ming University, Taipei 112, Department of Life Science, Graduate Institute of Biomedical Electronics and Bioinformatics and Institute of Molecular and Cellular Biology, National Taiwan University, Taipei 106, Taiwan., Huang HC; Institute of Biomedical Informatics, Center for Systems and Synthetic Biology, National Yang-Ming University, Taipei 112, Department of Life Science, Graduate Institute of Biomedical Electronics and Bioinformatics and Institute of Molecular and Cellular Biology, National Taiwan University, Taipei 106, Taiwan.
Jazyk:	angličtina
Zdroj:	Bioinformatics (Oxford, England) [Bioinformatics] 2014 Sep 01; Vol. 30 (17), pp. 2527-8. Date of Electronic Publication: 2014 May 02.
DOI:	10.1093/bioinformatics/btu306
Abstrakt:	Unlabelled: Exploring microRNA (miRNA) regulations and protein-protein interactions could reveal the molecular mechanisms responsible for complex biological processes. Mirin is a web-based application suitable for identifying functional modules from protein-protein interaction networks regulated by aberrant miRNAs under user-defined biological conditions such as cancers. The analysis involves combining miRNA regulations, protein-protein interactions between target genes, as well as mRNA and miRNA expression profiles provided by users. Mirin has successfully uncovered oncomirs and their regulatory networks in various cancers, such as gastric and breast cancer. Availability and Implementation: Mirin is freely available at http://mirin.ym.edu.tw/. Supplementary Information: Supplementary data are available at Bioinformatics online. (© The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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