[Evaluation of the linearity of pharmacokinetics of the phenolic antioxidant 4-methyl-2,6-diisobornylphenol upon intragastric administration].

Autor: Smol'iakova VI, Chernysheva GA, Ianovskaia EA, Gurto RV, Kuchin AV, Chukicheva IIu, Udut VV, Plotnikov MB
Jazyk: ruština
Zdroj: Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2014; Vol. 77 (2), pp. 31-4.
Abstrakt: The linearity of pharmacokinetics of 4-methyl-2,6-diisobornylphenol after single intragastric administration in doses within 10 - 200 mg/kg has been studied in rats. It has been established that pharmacokinetics of 4-methyl-2,6-diisobornilphenol in the indicated dose range is not linear due to a limited absorption of the drug from the intestine.
Databáze: MEDLINE