VEGF-A clinical significance in gastric cancers: immunohistochemical analysis of a wide Italian cohort.

Autor: Lastraioli E; Department of Clinical and Experimental Medicine, University of Florence, Largo GA Brambilla 3, 50134 Florence, Italy., Boni L; Clinical Trials Coordinating Center, Azienda Ospedaliero-Universitaria Careggi/Istituto Toscano Tumori, Largo GA Brambilla 3, 50134 Florence, Italy., Romoli MR; Department of Clinical and Experimental Medicine, University of Florence, Largo GA Brambilla 3, 50134 Florence, Italy., Crescioli S; Department of Clinical and Experimental Medicine, University of Florence, Largo GA Brambilla 3, 50134 Florence, Italy., Taddei A; Surgery and Translational Medicine, University of Florence, Largo GA Brambilla 3, 50134 Florence, Italy., Beghelli S; Department of Pathology and Diagnostics, University of Verona, Piazzale LA Scuro 10, 37134 Verona, Italy., Tomezzoli A; Pathology Division, Borgo Trento Hospital, Piazzale A Stefani 1, 37134 Verona, Italy., Vindigni C; Pathology Division, Azienda Ospedaliero-Universitaria Senese, Viale M Bracci 16, 53100 Siena, Italy., Saragoni L; Pathology Division, Morgagni-Pierantoni Hospital, Via C Forlanini 34, 47121 Forlì, Italy., Messerini L; Department of Clinical and Experimental Medicine, University of Florence, Largo GA Brambilla 3, 50134 Florence, Italy., Bernini M; General Surgery and Surgical Oncology, Azienda Ospedaliero-Universitaria Careggi, Largo GA Brambilla 3, 50134 Florence, Florence, Italy., Bencini L; General Surgery and Surgical Oncology, Azienda Ospedaliero-Universitaria Careggi, Largo GA Brambilla 3, 50134 Florence, Florence, Italy., Giommoni E; Medical Oncology, Azienda Ospedaliero-Universitaria Careggi, Largo GA Brambilla 3, 50134 Florence, Florence, Italy., Freschi G; Surgery and Translational Medicine, University of Florence, Largo GA Brambilla 3, 50134 Florence, Italy., Di Costanzo F; Medical Oncology, Azienda Ospedaliero-Universitaria Careggi, Largo GA Brambilla 3, 50134 Florence, Florence, Italy., Scarpa A; Department of Pathology and Diagnostics, University of Verona, Piazzale LA Scuro 10, 37134 Verona, Italy., Morgagni P; General Surgery, Morgagni-Pierantoni Hospital, Via C Forlanini 34, 47121 Forlì, Italy., Farsi M; General Surgery and Surgical Oncology, Azienda Ospedaliero-Universitaria Careggi, Largo GA Brambilla 3, 50134 Florence, Florence, Italy., Roviello F; Department of General Surgery and Oncology, University of Siena, Viale M Bracci 16, 53100 Siena, Italy., De Manzoni G; Division of Surgery, University of Verona, Piazzale LA Scuro 10, 37134 Verona, Italy., Bechi P; Surgery and Translational Medicine, University of Florence, Largo GA Brambilla 3, 50134 Florence, Italy., Arcangeli A; Department of Clinical and Experimental Medicine, University of Florence, Largo GA Brambilla 3, 50134 Florence, Italy. Electronic address: annarosa.arcangeli@unifi.it.
Jazyk: angličtina
Zdroj: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology [Eur J Surg Oncol] 2014 Oct; Vol. 40 (10), pp. 1291-8. Date of Electronic Publication: 2014 Apr 12.
DOI: 10.1016/j.ejso.2014.03.028
Abstrakt: Purpose: The clinical significance of VEGF-A expression in gastric cancer (GC) has been reported with contradicting results. We analyzed the expression and clinical significance of VEGF-A in a wide Italian cohort of GC specimens.
Methods: VEGF-A expression was tested by immunohistochemistry in 507 patients with GC of all clinical stages. The impact of VEGF-A on overall survival (OS) was evaluated in conjunction with clinical and pathological parameters.
Results: In the Italian cohort we studied VEGF-A was not an independent prognostic factor neither at the univariate nor at multivariate analysis.
Conclusions: Although frequently expressed, in our study VEGF-A was not able to discriminate between groups of patients with different risk.
(Copyright © 2014 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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